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Carolynanna
>> Denizen of the Citizens Band <<
Canada
6556 Posts |
 Posted - 12/11/2004 : 10:37:26
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S'alright, I have no time lately neither.
I've been trying to read the same book for about a month now.
And my son likes me to read this Abarat series to him so....
Its my UK word of the day.
__________
Godfather of nothing, ancesters of none.
Black glasses and feedback took my sense of fun.
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Edited by - Carolynanna on 12/11/2004 10:40:09 |
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n/a
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4894 Posts |
Posted - 12/11/2004 : 10:38:39
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I picked up a Tom Robbins book from a second hand book shop/coffee shop a couple of years ago 'Still Life With Woodpecker' I only bought it because (and yes I know you shouldn't) the cover was good.
But the book was great too, loved it.
Sure Carolyn, now could you tell me if this makes sense:
Nearly all DNA damage is caused by endogenous factors, namely spontaneous deanimation of bases, DNA oxidation due to reactive oxygen species produced as a by product of normal cell metabolism or methylation of DNA bases by S-adenosylmethionine. The most common point mutation in human DNA is the deanimation of 5-methyl Cystine (C) to Thymine (T). If left uncorrected alterations such as this will be continued along replication resulting in multiple copies of mutated DNA. The repair pathway that deals with this kind of single base pair point mutation is the highly efficient base excision repair (BER) pathway. There are two types of BER, short patch repair and long patch repair. Short patch repair involves the alteration of a single nucleotide whereas long patch repair, as the name suggests deals with longer patches of damaged DNA, from two to fifteen nucleotides (Bernstein et al.) The BER pathway first removes incorrect bases, like a deanimated C to T, utilising a battery of enzymes within cells called DNA glycosylases. The glycosylases recognise a specific altered base in DNA and catalyse its removal. These work by hydrolysing the N-glycosylic bond between the base and the sugar of the deoxyribose. The base is then removed and this leaves an AP site which is recognised by an AP endonuclease, the major one in humans being APE1. The site and endonuclease are so called because of it recognising any DNA site that has a deoxyribose but is missing a base due to loss of a purine or a pyrmidine, hence apurinic and apyrimidinc (Lodish et al.). The AP endonuclease then acts to cut the 5’ backbone, phosphodiesterase activity removes the sugar-phosphate group altogether. This resultant gap is then filled by a DNA polymerase, in humans this is most frequently DNA polymerase â, the new dNTP is added and fixed into position with DNA ligase (DNA ligase III complex with XRCC1, a stabilising accessory factor) and the bases are once again complementary. Knock out gene experiments performed on mice with the prevalent proteins associated with this pathway have shown that certain removal of certain enzymes show a correlation with increase of certain human diseases (Fortini et al) Table X shows that certain glycosylases, DNA polymerase and XRCC1 knockout all have associated cancerous implications.
( )
Frank Black ate my hamster |
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Carolynanna
>> Denizen of the Citizens Band <<
Canada
6556 Posts |
Posted - 12/11/2004 : 10:41:54
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Hmmmm, that sounds just about right.
I'd have to see Table X to know for sure ;)
__________
Godfather of nothing, ancesters of none.
Black glasses and feedback took my sense of fun.
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kathryn
~ Selkie Bride ~
Belgium
15320 Posts |
Posted - 12/11/2004 : 10:46:23
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Tre, I agree with floop. There's no such thing as "being friends" after
a break up, in my humble opinion. You keep the bad stuff from the relationship but not the sex, and what, I ask, is the point of that?
But I also see the point of the free stuff.
I'm a hypocrite to say anything. I've kept in touch with a certain someone
for a quarter of a century. Anyway....
 I still believe in the excellent joy of the Frank |
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floop
= Wannabe Volunteer =
Mexico
15297 Posts |
Posted - 12/11/2004 : 10:48:39
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a chain-smoking cancer researcher. there's a book idea
ist es möglich für ein quesadilla skrotum zu lecken? beim sprechen der quesadillas von LBF, ja. ja in der tatheheheheheheehehee! |
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n/a
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4894 Posts |
Posted - 12/11/2004 : 10:56:47
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Haha, no one actually read it, glaring grammatical errors, I don't blame you it's dull. I wrote it and it bores the shit out of me.
Floop, do as I say not as I do... besides reading all of that work stuff stresses me enough to need a smoke. But if that book gets written, chain smoker with fabulous hair remember
Carolyn.. Table X... (I can't remember the correct way of referencing tables so until I do it's table X)
Table summarising main enzymes utilised in BER that have disease involvement when gene is knocked out. Adapted from Fortini P, Pascucci B, Parlanti E, Errico M, Simonelli V, Dogliotti E (2003) The base excision repair : mechanisms and it’s relevance for cancer susceptibility. Biochimie 85 1065
Kathryn, weak willed love I told you
[edit] science killed this thread, I have guilt... To avoid reading life of pi I started reading cather in the rye last night, I think I may save life of pi till christmas or something
Frank Black ate my hamster |
Edited by - n/a on 12/12/2004 07:17:49 |
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shineoftheever
> Teenager of the Year <
Canada
4307 Posts |
Posted - 12/13/2004 : 19:30:19
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i read "rule of the bone" by russell banks, really liked it.
i'm skint too, it means broke.
good ol' holden caulfield, enjoy tre! |
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apl4eris
~ Abstract Brain ~
USA
4800 Posts |
Posted - 12/18/2004 : 11:17:20
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Russel Banks reads a short story today (right now in a minute) on This American Life.
'On the Border Between Good and Bad. In this show, Russell Banks reads from "Sarah Cole: A Type of Love Story." This story of someone using the word love as they try to make sense of things is from his collection "The Angel on the Roof".'
You can listen here:
http://thislife.org/pages/descriptions/03/228.html |
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n/a
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4894 Posts |
Posted - 12/18/2004 : 12:45:56
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On my train journey today I read life of pi and the curious incident of the dog in the night time. Both were nice little reads, but not super exciting or life changing.
Have fucked myself over slightly however as I took these books one for the out bound journey and one for the return with a little pynchon for the duration. Looks like I need to go shopping.
Suggestions??
Frank Black ate my hamster |
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Carolynanna
>> Denizen of the Citizens Band <<
Canada
6556 Posts |
Posted - 12/18/2004 : 12:51:21
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Oooo ooo ooo
Tre, I'd bet you'd like the Observatory Mansions by Edward Carey, strange little tale.
__________
Godfather of nothing, ancesters of none.
Black glasses and feedback took my sense of fun.
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floop
= Wannabe Volunteer =
Mexico
15297 Posts |
Posted - 12/18/2004 : 14:34:33
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quote:
Originally posted by Tre
Suggestions??
recent books i liked:
GLAMOURAMA, Brett Easton Ellis
CHOKE, Chuck Palahniuk
THE BARBECUE BIBLE, Steven Raichlen
ist es möglich für ein quesadilla skrotum zu lecken? beim sprechen der quesadillas von LBF, ja. ja in der tatheheheheheheehehee! |
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Cheeseman1000
>> Denizen of the Citizens Band <<
Iceland
8201 Posts |
Posted - 12/18/2004 : 15:25:02
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I can only recommend 'Cry, The Beloved Country' by Alan Paton.
And if a double-decker bus
Crashes into us
To die by your side
Well, the pleasure and the privilege is mine. |
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n/a
deleted
4894 Posts |
Posted - 12/18/2004 : 18:23:14
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Thank you ladies and gentle peeps. Now all I have to do is find a book shop in Cornwall that sells proper books rather than the endless litany of Judy Astley chick novels I seem to find.
This could take some time
Frank Black ate my hamster |
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Carolynanna
>> Denizen of the Citizens Band <<
Canada
6556 Posts |
Posted - 12/20/2004 : 12:25:07
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Read mine, read mine, read mine!
hehehe.
__________
Godfather of nothing, ancesters of none.
Black glasses and feedback took my sense of fun.
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n/a
deleted
4894 Posts |
Posted - 12/20/2004 : 17:57:56
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pick me pick me!
Fret not lovely one, I try my hardest to read all books suggested to me unless they're suggested by tasteless fools, and obviously you are not or you wouldn't be on this forum!
Of course Simon could be the exception to that rule....
()
I've written them all down and am tomorrow going to the closest thing Cornwall has to a city, hah!
Frank Black ate my hamster |
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shineoftheever
> Teenager of the Year <
Canada
4307 Posts |
Posted - 12/20/2004 : 18:08:28
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i love topics about books because i'm at the library when i'm online so i can just go check the stacks for any book that anyone reccomends, think i'll go see if there is anything i haven't read by chuck pahlaniuk on the shelf, thanks floop!
tre, human punk by john king? just started it the other day seems ok but then i finally got the 7th dark tower book so i have to put HP on hold. my shellac loving friend is the one who reccomended human punk. |
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4894 Posts |
Posted - 12/20/2004 : 18:19:38
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I'll look into it! Thank you kind sir!
I had a friend who got so into the dark tower books when we were young it all got a bit weird, we almost lost him to fantasy at one point
Frank Black ate my hamster |
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Cheeseman1000
>> Denizen of the Citizens Band <<
Iceland
8201 Posts |
Posted - 12/21/2004 : 01:28:35
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Tasteless fool I may be, but that is an amazingly powerful book.
And if a double-decker bus
Crashes into us
To die by your side
Well, the pleasure and the privilege is mine. |
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n/a
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4894 Posts |
Posted - 12/21/2004 : 05:38:03
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Oh cheesey you knows I don't mean it. I'm off out to the book shop now!
Frank Black ate my hamster |
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Carolynanna
>> Denizen of the Citizens Band <<
Canada
6556 Posts |
Posted - 12/21/2004 : 09:23:22
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I know I always say this one but I'm sure you'd like it too tre.
Its called Frank's World by George Mengels (There's a Frank in the title...;)
Its about Frank who is a karmic piece of garbage that goes polluting the souls and the balance of the universe with his vomitous prose and aura. Its full of rants that go on for pages. Very strange and different.
__________
Godfather of nothing, ancesters of none.
Black glasses and feedback took my sense of fun.
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Edited by - Carolynanna on 12/21/2004 09:24:25 |
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4894 Posts |
Posted - 12/21/2004 : 09:35:00
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I'll add it to my list
Cornwall is a dive, there is NOTHING here, grr, not one of the suggested books did I find. Ended up geeking out on sci fi.
Which reminds me, Carolynanna that sounds great! Ever read a book called Geek Love? can't remember the author off the top of my head and being at my mothers I can't check my book shelf (I miss my bookshelf(s)). About a circus family the mother a middle class girl turned geek (chicken biting variety) and the guy who owns the circus, they fall in love and decide to have their own freak children by various drug and chemical and radiation exposure, Arturo the fish boy.. great stuff...
[edit] mis-spelling due to my brothers sticky keyboard, I DO NOT want to know
Frank Black ate my hamster |
Edited by - n/a on 12/21/2004 09:36:35 |
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Carolynanna
>> Denizen of the Citizens Band <<
Canada
6556 Posts |
Posted - 12/21/2004 : 09:36:52
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No, but let me know when you find the author tre and I'll add it to my list :)
Its cool because I found a guy who works at the local bookstore who has exactly the same taste as I do and he's read a plethora of stuff so I don't have to wade through crappy books anymore. He just tells me what I'll like and I always do.
__________
Godfather of nothing, ancesters of none.
Black glasses and feedback took my sense of fun.
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Edited by - Carolynanna on 12/21/2004 09:41:16 |
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apl4eris
~ Abstract Brain ~
USA
4800 Posts |
Posted - 12/21/2004 : 09:52:11
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| Katherine Dunn (sp?) wrote Geek Love -it was one of my favorite books! |
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4894 Posts |
Posted - 12/21/2004 : 09:54:45
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Thats the badger! It's a brilliant book, it's one of those comfort books you can turn to like an old friend, you know what I mean?
Frank Black ate my hamster |
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apl4eris
~ Abstract Brain ~
USA
4800 Posts |
Posted - 12/21/2004 : 09:59:26
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Yep I do. Although I used to just think about it and feel warm and good. I haven't read it more than once, but I'm thinking it's good winter/holiday-time reading (to escape to the comfy fringe), if I ever get through all the other books piling up at the bedside.
uh...not likely |
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Russell Banks (And the bare necessities)
